Peptidylglycine amidating monooxygenase

These structures strongly suggest that the PHM reaction proceeds via activation of substrate by a copper-bound oxygen species.

They noted that the NEC1 gene (162150), which encodes another enzyme important in posttranslational processing of neuroendocrine precursors, prohormone convertase 1 (PC1), is located in the same region (5q15-q21). They noted that the NEC1 gene (162150), which encodes another enzyme important in posttranslational processing of neuroendocrine precursors, prohormone convertase 1 (PC1), is located in the same region (5q15-q21). (1994) mapped the Pam gene to mouse chromosome 1 in 3 individual backcrosses.

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AB - Many neuropeptides and peptide hormones require amidation at the carboxyl terminus for activity.

Peptidylglycine α-amidating mono-oxygenase is an enzyme found in large dense core vesicles which acts on the final steps of biosynthesis, converting the peptidyl-Gly into the corresponding peptide-NH2.

PAM-related pathologies are characterized by an increased relative abundance of α-amidated neuropeptides.

Last modified 16-Jan-2020 14:46